SAMe | Pure Encapsulations® | 60 Capsules


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S-Adenosylmethionine Supplement

Support Joint Comfort, Liver, and Cognitive Function*

• Overall Health: Provides support for cell membrane fluidity, neurotransmitter synthesis, glutathione production, joint comfort, methylation, and healthy cell growth. *
• Positive Outlook: SAMe supports a positive outlook and cognitive function. *
• Joint Health: SAMe supports joint comfort and function by supporting healthy proteoglycan synthesis, and by helping to stabilize the proteoglycans. *
• Pure Quality: Our supplements are made with only premium ingredients sourced from trusted suppliers and guided by our nutritional experts, then carefully manufactured and tested to verify their potency and purity.
• Pure Difference: What makes us different isn't just our process or what goes into our supplements -- what we leave out matters, too. Pure Encapsulations products are FREE FROM wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives.


Product Description

SAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. SAMe also promote healthy mood balance, as indicated in over 40 clinical studies. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood, believed to be due to its support for neurotransmitter monoamine synthesis and function, including dopamine and serotonin. It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity. Studies suggest it supports joint flexibility and comfort in individuals with osteoarthritis as well. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. It is believed to relieve osteoarthritis pain by supporting proteoglycan synthesis, as well as helping to stabilize and protect the proteoglycans.


• Vegan
• Non-GMO
• Vegetarian
• Helps relieve pain due to osteoarthritis
• Helps to promote healthy mood balance
• Made with hypoallergenic, vegan ingredients
• Manufactured using a solvent-free manufacturing process
• Provides 200 mg per capsule of enhanced-stability form SAMe

Medicinal Ingredients

(Per capsule): SAMe (from S-Adenosyl-L-methionine disulfate tosylate) 200 mg.

Non-Medicinal Ingredients

Vegetarian capsule (hypromellose, water), Hypoallergenic plant cellulose, Calcium oxide, Ascorbyl palmitate, Calcium chloride.

Recommended Dose

Adults: For healthy mood balance, take 2 capsules 1-3 times daily. For osteoarthritic pain, take 2 capsules 3 times daily. Take in divided doses, between meals, or as directed by a healthcare practitioner. For osteoarthritic pain, use for a minimum of 8 weeks to see beneficial effects. Consult a healthcare practitioner for use beyond 12 weeks.


Do not use if you are pregnant, breastfeeding or have been diagnosed with bipolar disorder. Consult a healthcare practitioner prior to use if you are taking medication such as antidepressants, hepatoxic drugs or monoamine oxidase (MAO) inhibitors. Do not take at night, as the product may cause anxiety, restlessness and insomnia. Consult a healthcare practitioner if symptoms persist or worsen. Some people may experience mild gastrointestinal upsets, anxiety, restlessness, insomnia, hyperactive muscle movement, and hypomania, in which case discontinue use and consult a healthcare practitioner.
Store sealed in a cool dry area. Use only if the safety seal is intact.

Safety Information

If you are pregnant or lactating, have any health condition or are taking any medication, particularly if you have bipolar disorder or are taking antidepressant medication, consult your health professional before use.


Each serving size (1 vegetarian capsule) contains: SAMe (S-adenosylmethionine) 200 mg (from S-adenosyl-L-methionine disulfate tosylate). Other ingredients: Vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose), calcium oxide, ascorbyl palmitate, calcium chloride.


As a dietary supplement, take 1 capsule, 1-2 times daily, between meals, or as directed by a health professional.

Legal Disclaimer

These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Please contact your healthcare professional immediately if you experience any unwanted side effects. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product.

†All Pure Encapsulations ingredients, including those derived from corn, are GMO-free. We obtain statements from each of our suppliers certifying that the ingredients do not contain GMOs. For some nutrients, we conduct PCR testing to confirm the absence of genetically modified material.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Actual product packaging and materials may contain more and different information than what is shown on our website. We recommend that you do not rely solely on the information presented and that you always read labels, warnings, and directions before using or consuming a product.

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